Your situation sounds similar to mine, in that those are the two medications my doctor has recommended, and my body has reactions to fosomax. I am worried about the infusion reaction also, based on my prior reactions. I look forward to hearing about how this works for you.

Hello @pammy816 and welcome to Mayo Connect. As a person who also has osteoporosis, I understand your concern over selecting the right treatment. As you read the posts of others who have tried different medications, it is important to remember that everyone reacts differently to medication.

I also tried an oral osteoporosis medication at first and had GI problems. Previously, I took Evista, also an oral medication, with no problems at all. There really is no "one-size-fits all" when it comes to any treatment. Like us all, in this forum, we each need to try a treatment plan that will benefit the bone loss we are experiencing. If it doesn't agree with us, our medical team can always find another treatment plan.

I look forward to hearing from you again with any other questions or concerns. Will you continue to post as you work on this decision?

I had the same reaction to Fosamax along with heartburn and diarrhea. I also stopped after 2 doses. I switched doctors and am now on Forteo (I was on this before but my previous doctor took me off because of increased alkaline phosphotase numbers. This new doctor said that's normal with Forteo.) Not sure what I'll do after my two years because I too am worried that I'll get the same muscle aches from Reclast. I guess I'll cross that bridge when I get to it. Good luck with your decision. Keep us posted.

In 2008 I took Fosamax for about 3 months. No GI issues but one day I could hardly put weight on my right leg. I had pain from the hip on down. I stopped taking the med and my chart was flagged to not have it again. Over all these years, my numbers didn't change that much-not good but not worse. Fast forward to 2023 and a worsening in my spine alarmed me. In January of this year I agreed to try Reclast after speaking with friends and family who had no issues. The infusion was fine then about 10 hours later I had extreme pain in my ribs, side and upper back, dizziness and fever. It subsided over the course of the next day and after several days I felt fine. About 2 months later, I began having a lot of musculoskeletal type pains in my leg, both knees and hand. It lasted about 3 months with varying degrees of discomfort then abated for about a month only to begin again recently. My Dr. said that about 40% of people have similar side effects. It has affected me in a way that I could not be as active as before-walking, hiking, even gardening sometimes is difficult. I'm not sure the trade off is worth it. I won't know until my next scan but am leaning toward not repeating this medication come January. Everyone is different but I wish I had known this before taking it as it affects my quality of life.