I have been following some version of a B1 protocol for about 2 months, and throughout, I have had to make regular adjustments in my dosing, because while I am very sensitive to B1 and know that I should take things slowly, I occasionally let my impatience get the better of me, and will then titrate up too quickly, only then to experience a setback in my symptoms (upper respiratory, mostly). I have also been regularly updating, all this time, what I take with my B1, as I learn about B1's synergistic relationships with certain minerals and other B vitamins. I have had some very good days along the way, but I am still very far from stable in my improvement. Relevant here is that I recently came to understand that two prescription medications that I had been on for years might be getting in the way of my responding to B1 faster, and so while I tapered off of these drugs (under medical supervision), I needed to focus on any changes that these tapers brought about. Dr. Derrick Lonsdale, in the latter years of his work, voiced strongly his certainty that many prescription meds that we take can interfere with B1 absorption, and the meds I was on are, moreover, infamous for causing spikes in patients´ bradykinin levels (causing harmful vasodilation throughout the body and respiratory symptoms associated with this vasodilation). It will take weeks or months for the lingering effects of my tapered medications to resolve, and so I look at my B1 protocol experience as something that I will essentially have to start again from scratch once more time has passed after cessation of my offending meds. But there is one sign that I am responding very meaningfully to B1 already, when I consider how my blood pressure has fared. When I tapered off of my medications (both for hypertension), I had already been taking some dosage of B1 daily. To my amazement, once I was drug-free, my blood pressure was maintaining at very safe levels without any medication, leaving me to conclude that my B1 dosing was probably yielding one of the best loved benefits of B1, i.e., reduction of high blood pressure.