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I, a 79-yr old Indian American woman, am about to complete my Tymlos treatment and had bllod work done before meeting my Endo.
- My basic metabolic panel #s are normal.
- CTX is 321
- P1NP is 49.
After joining the Mayo Osteo group, I learned about CTX and PiNP markers for OP. I don't have any CTX and P1NP values to compare with. For these stand-alone #s, any guidance on what these #s mean?
Thanks
Replies to "I, a 79-yr old Indian American woman, am about to complete my Tymlos treatment and had..."
@rajmayo22, hi.
From your numbers I would guess that you are having good response to Tymlos. If you are completing a second year, depending on your dxa results, you might want to ask your provider about taking Tymlos for a third year.
Bone markers are in the toss currently. Protocolled use of bone markers is for determining whether a medication is effective. That would require before medication use testing, and, usually, during medication use testing. It is becoming less fringe to use one set of markers in comparison with each other. This video at 9 minutes and 22 seconds, from an impressive (but very expensive) md, outlines a math method for determining the ratio between P1NP which measures a bone fragment indicating bone acquisition against a CTX protein fragment indicating bone loss.
These bone markers (especially CTX) fluctuate during the day, after eating, with exercise, with the use of biotin and collagen.
With the use of PTH therapies P1NP is said to rise faster than CTX, until the osteoblasts stimulate a rise in osteoclasts and the CTX catches up.
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maybe this will help: https://www.mayocliniclabs.com/api/sitecore/TestCatalog/DownloadTestCatalog?testId=83175
https://food4healthybones.com/wp-content/uploads/2022/10/The-Importance-Of-Bone-Markers-With-Dr.-Keith-McCormick.pdf