@pfurcht123According to the information sheet I received with my prescriptions and what I read online when researching each antibiotic Azithromycin and Ethambutol can be taken with or without food. Rifampin should be taken on 1 hour before or 2 hours after a meal. Also, the probiotic should be taken 4 hrs or more before/after the antibiotics. I was afraid to take all this on an empty stomach so I started with Azithromycin and Ethambutol in the morning after breakfast. I take the probiotic at 12N so it's a good 4 or 5 hours later. Then I do the Arikayce at 5PM . We finish dinner typically by 6:30 so then I take the Rifampin at 9:00 before bed. I was nauseous the first couple of weeks so I bought some acupressure wrist bands which did help. After a few weeks the nausea went away and this schedule works well for me.

Whatever works for you as long as rifampin is taken without food. For me, all spread apart as much as possible with AZ with a big dinner

I was told or read that rifampin should be taken two hours after food or one hour before.
I have trouble sleeping and usually wake up at 2 a.m. or 3 a.m., so I get up and take my
two rifampin. Then the Azithromycin and Ethambutol partially with breakfast and partially
with lunch. Started Feb. 5, so far no problems other than slight diarrhea every week or two.
I'm lactose intolerant and tried Florstor and it wiped me out.
Submitted sputum samples last week but haven't heard results yet.
Harry