What options for poorly differentiated carcinoma, Keytruda failure

Posted by rick1952 @rick1952, Jul 23 6:49pm

Have poorly differentiated carcinoma of unknown primary, Stage 4, diagnosed 06/2022. Initial treatment with FolFOX and then added Keytruda when PD-L1 returned positive. With Keytruda enlarged lymph nodes rapidly resolved. Now recurrent disease despite ongoing Keytruda. Awaiting recommendations for additional therapy. Had extensive staging: CT, PET, 3 lymph node biopsies, EGD, Colonoscopy, EUS, Capsule study, Genetic studies, etc.
Are there others with Stage 4 carcinoma of unknown primary and Keytruda failure?

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Colleen Young, Connect Director | @colleenyoung | Jul 31 1:48pm

@rick1952, there is another active discussion with members dealing with cancer of an unknown primary here:
- Anyone have cancer with unknown primary?
https://connect.mayoclinic.org/discussion/rennie/
@cindylb shares a similar story to yours here https://connect.mayoclinic.org/comment/333576/ where Keytruda worked at first and then failed as a maintenance therapy for carcinoma of unknown primary. His cancer was being treated with protocols commonly used for lung cancer. @frankbc may also have experiences to share.

Rick, have you learned what next steps will be recommended?