I works by activating your immune system and also down regulates your microglia that are part of your nerves support system. They are resposible for telling your nerves that you need inflamation. (Even if you don't) There is loads about how it works on the Net. Just look it up. BTW: I was on 9 mgs of Budesimide (for a number of weeks) when I started the LDN. I was able to taper off of it. The usage for opioids is usually not the low dose level.