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Testosterone levels are rising after cessation of ADT
Prostate Cancer | Last Active: Aug 1 10:47am | Replies (12)Comment receiving replies
Your question raises an interesting question...First, my clinical history (see attached).
After finishing triplet therapy with my last 90 day Lupron shot in May 18, my T rose to 135 by October then 481 by February, eventually 608 in March 2023 when we started back on treatment. After stopping Orgovyx on 3 April after a year, 90 days later T is 328, PSA .001, side effects, gone.
How long will this "vacation" last, who knows but I feel great!
I pondered, well, mused with my medical team, why, if T is the fuel for PCa, did my PCa not "return" until 2022 when it began its rise from .06 to ,77 a year later? The other question we pondered is why my T recovered so rapidly and higher, considerably, than when I started triplet therapy which was 297 when tested at Mayo.
No definitive answer.
As other have said, I'm a layman, no formal medical training, education, or board certifications.
What I do know is the side effects dissipated, hot flashes, fatigue, muscle and joint stiffness and genitalia shrinkage.
So, enjoy, continue to actively monitor your PSA, T and other blood values as appropriate.
Kevin
Replies to "Your question raises an interesting question...First, my clinical history (see attached). After finishing triplet therapy with..."
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That is a very good outcome at least for now if you ask me. Your T recovers to levels at which you can rebuild muscle mass which is important to metabolic health.
I'm not a biochemist or similar but my understanding is that long term ADT can cause some cancer cells to perish and others to be damaged or place them into a state of inactivity. How many millions of cancer cells survived your treatment to some degree and are "sleeper cells?" It takes a lot of them to get the PSA meter to budge.
I'm about to enter the first ADT-free phase of my treatment after 2 years of intensified therapy. Trying to figure out everything I can do to improve the ability of my immune system to keep any residual cancer in check in the presence of T. I haven't seen a lot of literature on this particular scenario.