I am still not positive that the hydroxy is causing it. I may stop it for a few days and see what my body does. I did not take it yesterday morning and still had the issues, but just missing one dose may not do anything. I am getting tests to determine whether my leg pain is PMR or something else, like poor circulation. Who knows, maybe I am in PMR remission and the leg muscle pain is something else. This growing old is a challenge!