Erleada and Lupron: Anyone have late appearing side effects?

I'm sorry to hear that. I've never had nausea or diarrhoea because of ADT (Firmagon/Orgovyx) and Erleada over the past 3 years — when it's happened, it's always been obviously related to a bug going around or something I ate, and it's never lasted longer than 2–3 days.

(Layperson writing) As I learned after a bout of in the tropics years ago, prolonged diarrhoea puts you at risk of dehydration and other serious issues, so it would be a good idea to see your physician as soon as possible and try to sort it out. If you start to feel weak, dizzy, or confused, consider going straight to the emergency room (don't drive yourself).

@dwheels8

After being on Eligard for 2 months and the combo Eligard plus Erleada for almost 2 months no diarrhea but I have lost my appetite. In part perhaps due to a rather monotonous plant-based diet so I am treating myself to a few meals of plant-based meat every week. Last PSA a month ago was 2.01ng/mL down from 24.96ng/mL a month before that. Rather have a loss of appetite than be gaining weight. Waiting for the combo hormone therapy to shrink tumors significantly to begin a directed therapy.

As always good luck on your prostate cancer journey!

hey brother , ive been on Lupron and Arleta since late April , I found out in late dec that I had cancer removed my prostate jan 9th , jan 15 found I was stage 4 metatastic, and im. only 60 with a Gleason score 4+5=9 been going to Houston to MD Anderson I have lost close to 50 lbs and my PSA Is looking awesome , its down to a .04, but her is the kicker the side effects are pretty significant , was trying to send you pics of the effects from something , they say its not the Arleta, so I get a hot flash I get sick don't like to eat can't hardly sleep , but they say its better than the alternative .

well good luck

I can't guarantee that your experience will be the same, but after 3 years on ADT and Erleada, the side effects have become much-more tolerable for me — more of a nuisance than something that affects my quality of life. Getting off an injectable (Firmagon) and switching to daily pills (Orgovyx) for the ADT made a big difference.

Erleada and Abuteriene are no longer working. PSA is 74 and climbing… what’s next?
Dr suggests Pluvicto?
Any luck with stem cells?

To “dwheels8”, My experience with Lupron shots for 2 years were the side effects of hot flashes, body hair loss, and loss of energy and strength. Never had Erleada so can’t comment on that.
(My Lupron side effects started in about 2 weeks so hope you enjoyed your ‘free ride’ while it lasted.)
Maybe consider quizzing your oncologist if you could try another combination to by-pass the worst side effects.
We’re just follows in this PC club so assert yourself to your doctors till you get what seems best for YOU.