My PC when diagnosed was Gleeson 10, stage 4, with some local metastases and one metastasis to a lymph node in my chest. Most docs won’t do chemotherapy because they cite a study saying it’s not effective. However, the study did not include doing multiple steps in close succession or simultaneously, which is highly effective. I switched my care to doctor Eugene Kwon at Mayo Rochester, immediately started Lupron, had Docetaxel chemo, then eternal beam radiation. His goal was to get me clear and keep me that way for at least 10 years. I was clear within 8 months and have been clear for 1.5 years. A friend had PSA of 4500 (yes), many metastases and is now clear. If you want to live, I suggest you watch his videos on YouTube. Search under his name and prostate cancer. There should be about 4 videos. My wife found these and saved my life.