I take 36,000 mg Creon with meals, but I find that smaller meals, 5 to 6 times a day, to be less difficult to digest. As the Creon causes constipation (and it seems, occasional diarrhea as well) I was hoping to reduce the Creon intake from 36,000 a meal to 18,000 (3 x 6,000).

The other issue with taking Creon is the size if the meal, amount of fat in the meal (so I am told, but I often wonder, who really knows for sure 100% of anything).

The bladder issues "seem to be" related to constipation; the bladder has issues operating properly if constipated. I have had several medical tests that ruled out anything else. My urologist, who is well respected, politely said that in the grand scheme of my issues, I am simply lucky that I only have occasional bedwetting at night, and only a couple of times per month. Some people with EPI have bowel accidents much more often than I do, and ultimately it seems constipation can cause problems with the nerves muscle control.

Re: cancer. There were some tests that came back originally that had indicated it could be a concern. There were so many tests and scans when this all began that I can't tell you what it was, as it was both physically and emotionally overwhelming at the time and I just pushed through it all.