I have had daily headaches since I was 14, I am now 68. I have tried just about everything on the market. Have had all kinds of tests done. The only thing that ever helped was aimovig a once a month shot. It was such a relief to not have a headache. Then after about 9 months it just stopped working. I had to go to a pain clinic in order for a rx to get it. I will be going back to the pain clinic to see if they have a different medication to try. Try to get into a pain clinic to see what they can try. Make sure to list everything your wife has tried and what reactions or results were.