I recently watched a very new video with a rheumatology expert on YouTube who advised splitting doses, against the old standard of morning doses. You know, not much attention is paid to PMR, not much research, and many rheums know little about it.
I finally saw a really nasty rheum who told me I should have gone to an Internal Medicine doc instead. He refused to take me as a patient and asked, stupidly, why I was already on prednisone, 8 months in with an experienced internist in the house. Dumbfounded by that question, I asked him if he had any idea how painful this is? He said, "No, I don't."
For me, starting on 20 with just my husband's advice, I couldn't make it through the night until I split the dose, 4am and 4pm. I woke up in agony at 2am.