I had Stage 1A lobular cancer in my right breast, Had a lumpectomy with clear margins and radiation therapy, No chemo, as lobular breast cancer doesn't respond to chemo. No cancer found in my sentinel lymph node. After a year, I was given the all-clear. I was on Anastrozole for 14 months and asked to be taken off last month. Initially, the only symptom was hot flashes. But then, out of the blue, I became very emotional. I would cry over nothing and would feel overcome by waves of sadness would come and go. I had never had a problem with depression before. Since being on Anastrozole, my triglycerides went from 150 to 216. I also developed severe pain in the joints of both hands and in my hips and lower back. I have osteopenia and since I can't have another bone scan until February, I don't know how being on the med affected my bones. Based on My Oncotype DX score, my risk for recurrence is about 8%. Staying on Anastrozole would reduce my risk to 4%. I decided that quality of life was more important so I made the decision to go off the drug. I have been off it for 5 weeks now and the pain in my joints is gone as is random spells of the blues. If my cancer comes back, I will deal with it. But for now, I'm enjoying my life one day at a time.