I am 67 years old and was diagnosed with Stage IV, Gleason score 4+4 almost 4 years ago. Six months after starting on Lupron and Zytiga, I had 28 sessions of radiation. So far so good! It was not easy. I had a catheter installed during radiation and they removed it after a month. My PSA is 0.2 today (last quarter my PSA was 0.1) and I feel good. Been off Lupron and Zytiga for a year and a half. I feel great. I exercise daily, weight up a bit at 204 (I'm 6'1") Keep fighting and make sure you consult with your oncologists.