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Hi mayblin, Has anyone on here has ever started a discussion for sharing the causes of our OP? That would be really interesting. If there isn't one already, I think it would be cool if you started one.
In my case, I may not have reached my full bone density potential. That's probably true, but I did gymnastics and cheerleading--lots of impact exercise--so that can't be the whole story.
Here's the list of potential contributors that my endocrinologist and I discussed:
I was malnourished as a child and young adult.
My hormones have been a mess since puberty. There was a whole year when my menstrual cycle stopped, and perimenopause started in my early 40s.
I have anxiety, and stress out easily, so I suspect my cortisol levels are high--not yet tested.
I got Giardiasis (a parasitic disease) when living in rural Thailand. I had it for several years before it was diagnosed. That may have had lasting effects on my digestive system causing further malnutrition as an adult.
Finally there's a genetic component--my 80 year old mother has had osteoporosis since her mid-50s.
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@hopefullibrarian thank you very much for sharing your personal story and experience. The sequencing you are doing isn't that common. There was a paper published on 2021 with results of this sequencing examing 2 doses of prolia followed by 12mo evenity, bmd results in table 2:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260819/
Very likely 1 dose of prolia followed by 12mo evenity will have similar results and you are in the clear. Note that evenity's effect was attenuated after 2 doses prolia, however, overall bmd% increase with prolia to evenity holds well when compared to evenity alone during same time frame.
Between the two bone markers, ctx is more variable in nature but you had controlled all the premetrologic cause of variability in your power. That said, the overall variability of the markers is 10-15% measured in serum according to publications. If ordering and payment of btm testing are not a problem, getting them monitored frequently will offer lots of information. Please keep us posted and best of luck!
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I also did not eat well as a child…I took nexium for 10 years….synthroid for 30…all contribute to osteo. I am doing the testosterone pellets etc. my dexa scores have improved since diagnosed ten years ago. I also take supplements exercise etc.