I was on lupron prednisone5mg and zytiga with 20 rounds of radiation when i was first diagnosed with psa13.4 after 18 months i stopped everything psa went to undetectable for 18 months then started climbing backup i had mets to the pelvis and the 9th rib and the spine and my ishium 3.4 tumer went for another 5 round of radiation and lupronpsa now is 0.05 pet showed tumer is shrinking mets are almost gone tried adding xtandi but my bloodpressure went thru the roof stopped it after 6weeks staying with the lupron getting my other hip replaced next month age 72 . feel pretty good.I guess ill stay with the lupron as long as it works until it gets resistant.then who knows.