@kc43 how interesting that the initials in your mayo name of @kc43, is the exact initials of of my wife Kim C. who is doing better. After being diagnosed in April 2022, 9 cycles chemo CAP/TEM, surgery and removal of mass on pancreas tail, gall bladder removal, and her liver had too many tumors on it originally, to do anything, but after the chemo (pill form), she had near 70% reduction from stage 4 they did the surgery listed. After monitoring it, and switching from Lanreotide to Ocretide, our team wanted us to consider a liver transplant, after doing 4 cycles of PRRT ending this past March. Fortunately, the PET scan revealed even further reduction in the remaining tumors in her liver, the only remaining spot of NET per the PET scan. In answer to your question, in our case, she tolerated the PRRT treatments, the 1st one was almost seemless, no nausua, just a bit tired. The 2nd one she was real tired, but not much nausa. The last two went ok, and but the wait for 90 days after the last cycle was mentally the worst, not knowing whether the NET had started growing again, or if the PRRT treatments had at least stopped the growing or reduced the tumors remaining. For now our team is pleased with the progress and relative appearance of the liver on PET scan and MRI, it looks pretty healthy, for now. We may still consider the liver transplant down the road if needed, and just be inactive on the transplant list for now. I hope this gives you some information, as I'm sure your aware that everyone has different reactions to the PRRT treatment. She is 60 years young, and did better than we expected, and more importantly good results for now. Please let us know what other questions you may have on this fight that we share with everyone in this group. We all got this!