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CTX Marker

Osteoporosis & Bone Health | Last Active: Oct 6 11:06am | Replies (77)

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@mayblin

Prolia 8mo prior explained the low "baseline", thank you! Out of the three anabolics that are available, you and your endo picked the best one for your situation, in my opinion. What was your reasoning behind this choice?

Evenity's effects on bmds and btms are published in different trials, they more or less have similar results or trends. Your btms results especially ctx might be complicated by prior usage of prolia. Could now be the rebounding period when the antiresorptive effect of evenity is not enough to compensate it? You don't have a true baseline of ctx to compare to. The good part though, is that your p1np showed a great response to evenity early on at 2.5 mo, and is still trending higher (maybe start to plateau) at 5.5mo (this is a point when many trial data showing p1np dropping back towards baseline). Unlike forteo or tymlos, evenity building bones mainly via modeling process from what ive read (someone please correct me if this statement is incorrect). Because of this you may well see a good dxa improvement despite a "jump" (increase ~50%) ctx this time with "only" ~17% increase in p1np since coupling is not too relevant here. Time will tell. It will be nice to keep monitoring btms to see how the two will be trending. Wish you the very best going forward!

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Replies to "Prolia 8mo prior explained the low "baseline", thank you! Out of the three anabolics that are..."

Mayblin, Thank you! I chose Evenity because it acts fast, provides the best results, and was recommended to me by three specialists. My first DEXA T-scores in 2023 at 53 yrs were lumbar spine -3.7, and left femoral neck -3.2, and I had had a compression fracture in 2020, so it made sense.