@astaingegerdm - Thanks for your input regarding your experience regarding Collegenous Colitis. You said having Methotrexate injections weekly X 4 weeks worked...and it did not return. Did you just do the 4 weekly injections and have not had to take them again? Sounds great. Also was the Imuran not ever used for C. Colitis? Just the other GI autoimmune condition? Sounds like you incorporated the Pepto Bismol along the way. Did you have to use it very often or just until you were able to discontinue it once you were given Methotrexate. Again, thanks.