Yes, PSMA can show where advanced prostate cancer is located. However, at lower PSAs, PSMA PET scans are less sensitive to prostate cancer (see attached chart).

Also, about 15% of prostate cancers are PSMA negative (or PSMA naive) such that PSMA PET will often miss them even though you know something is wrong due to the increasing PSA.

That’s where other types of PET scans that aren’t reliant on PSMA (like Axumin PET scans) may be helpful. Always consider the full set of tests/calculations that are available.