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How Have Your Glioblastoma Experiences With Temozolomide Been?
Brain Tumor | Last Active: 1 day ago | Replies (51)Comment receiving replies
Here is an explanation of MGMT: Resistance to alkylating agents via direct DNA repair by O6-methylguanine methyltransferase (MGMT) remains a significant barrier to the successful treatment of patients with malignant glioma.
A biopsy reveals whether the tumor is positive or negative for MGMT via DNA analysis. Being positive for MGMT means the chemotherapy is moroe likely to be effective.
There are other, completely yet unknown factor(s), which also influence the effectiveness of chemotherapy per Dr. Sherman , our neuro-oncologist. The doctors know this because some people who are MGMT positive still respond favorably to chemotherapy. So, being negative is not a reason to forego chemotherapy in my (non medical person) opinion.
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So if MGMT promoter methylation was not detcted is that good or not so good.
I'm still trying to figure things out.
thanks for your reply
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According to my path report Mayo Clinic states: The therapeutic and prognostic implications of MGMT promoter methylation status have best been studied in Glioblastoma. The presence of MGMT promoter predicts response to alkylating chemotherapy (i.e. temozolomide) and is a FAVORABLE (emphasis is mine) prognostic factor got patients with glioblastoma. Additional studies are needed to assess the clinical significance of the presence the presence of MGMT promoter methylation in other tumor types.
My own neuro-oncologist has told me several times that that the presence of MGMT promoter methylation is a good thing for me to have.
I just completed my 6 weeks of rad/temozolomide and am in my medication vacation. I had few side effects-primarily a bit of fatigue. I’m now celebrating at the beach! I will be discussing using the Optune device along with 6 more rounds of temozolomide.