I was diagnosed with PMR 6 weeks ago although symptomatic much longer. I was advised by my primary care not to pursue the prednizone treatment as it may result in needing insulin th manage my type 2 diabetes. My rheumatologist prescribed 15 mg of methotrexate weekly and then increased to 20 mg after 4 weeks. Methotrexate is not a pain medication and only addresses the inflamation at what seemed to be a snails pace. But here is what has happened gradually over 5 weeks. I could not raise my arms over my head. I had great difficulty getting out of bed and up and down from a sitting position. Both hips, shoulders and knees were badly affected. I could barely walk without taking 4000mg of tylenol a day. I gradually realized the pain in my hips disappeared. I can now raise my arms over my head and comb my hair in the morning. I can walk my dog and I can get up and down easily. I do get flare ups usually from over doing and I am limited in the type of swimmingni can do as I still cannot route my shoulders without pain. Now I need to build back my upper body strength. For those that are considering methotrexate to treat PMR keep a hoirnal so you can watch your progress as it is very slow and subtle. I have been fortunate with mild side effects...very mild nausea morning after that is resolved by a couple of crackers, tired for a couple of days and flare ups for a couple of days of joint pain but noticeably less intense and treatment continues. I am down to 2000 mg of tylenol a day. 3rd set of labs in 2 weeks so we will see if my kidneys and liver are still not affected. One thing I have learned is much like the disease the treatment, regardless of type affects everyone differently and I am very fortunate in my outcome so far. I hope this helps anyone that is afraid of using methotrexate for treatment in making their decision.