I was diagnosed with MAC and Bronchiectasis in Oct of 2022. I had a bronchoscopy and CT scan. I was started on Clarithromycin, Ethambutol and Rifampin. I was on those meds for a year and a half. I had one neg sputum test during that time, and 2 positives. My pulmonologist told me the MAC bacteria had become resistant to the antibiotics and he wanted me to have a piccline put so I could do IV meds for a month. I started Amikacin and Imipenem Cilastatin, in June 2024 and just finished those. I had a new CT ( I've had 5 total so far) and just saw a thoracic surgeon at the request of my pulmonologist. The surgeon told me that my CT, that I had done 2 days after finishing my IV drugs, looked worse that the one I had in Jan of this year. I have a cavity that has grown in size, that he thinks that is harboring and growing the bacteria and the only way to get rid of the bacteria is to take the cavity out by doing a lung resection. I am 69 years old, have been active through all of this - I walk at least 3 miles a day, work out at least 5 times a week, play tennis 4 - 5 time a week, ride my horse and do lots of yard work. (wearing a mask now!) I only felt sick when I first started the meds, which we adjusted and I was fine after that. No ill effects of the IV drugs either, even though my doctor said they were very toxic! I don't know what to do, If all of these meds have done nothing, is surgery the only way to get this taken care of?? Should I get another opnion? Has anyone had surgery due to MAC?