I did gain weight on Creon, but had lost so much weight prior that it was normal to get it back, and it did cut down on gas, flatulence, and diarrhea. What then happened was extreme constipation that could occasionally result in minor aches in the groin, so it was pretty bad. Sometimes I can go two weeks without diarrhea, then may have it 12 times in 12 hours, and is impossible to control, as it is like pure water. Then gradually I go back to normal again after a day or two. The back and forth seems impossible to predict, as it could happen ay anytime, and go away as quickly as it arrived. One doctor said this sort of extreme is common. Has this been the case for others with Pancreatic Enzyme Insuffcanly? I am about at my wits end, and having to worry about leakage, especially when traveling.