I've been on the methotrexate just over 2 weeks now (completed the 3rd week of dosing, slowly increasing up to the 7 pills ((total 17.5 mg)) that will be the dose I take once per week beginning this coming week). I've not experienced side effects thus far. Still have the soreness/pain in fingers/wrists and shoulders but I understand it will take a bit for the methotrexate to take effect. I have not totally given up alcohol but have cut back on frequency. Hopefully the liver will not be compromised. My labs so far have been good. I have not had any labs since adding the Methotrexate yet.