My husband had a BRAF (somatic) mutation so add that to the list. The FDA approved two drugs last year which may help extend o.s. by perhaps a few months for these tumor induced mutations. They were $2000 out of pocket for a month’s supply with good supplemental Medicare insurance. However, this year the Inflation Reduction Act has a cap of $2000 for Medicare patients.

He also had to drop a clinical trial that did much the same work. (Fit, strong, no other comorbidities even after two complete courses of ineffective chemotherapies sandwiched around the Whipple at top Boston cancer centers. He climbed a mountain 4 weeks before death.)

Also, know that genetic sequencing panels vary. Take the most complete one you can find at major cancer centers to find the location and type of replication errors.