How to Interpret a Negative Biopsy After Testing Positive......After a PSA score of 7, and a Transperineal Biopsy I was diagnosed by my local Urologist in late 2021 with Gleason Grade 3+3, with 1 of 12 (or 16 cores as I can't remember) with the one core testing 10% positive. The other cores were negative. Older Tech 1.5 Tesla Machine MRI showed a PIRADS 2. Placed on Active Surveillance. One year later, with a PSA of 5.7, the same Biopsy Tests confirmed Gleason 3+3. Wanting a second opinion, went to a regional NCI Comprehensive University affiliated Hospital for just a new 3.0 Tesla MRI. A PIRADS 3 lesion of approximately 4 mm was noted. Still on Active Surveillance. In April 2024, a new PSA showed 8.0. Never been that high. Sought a second opinion from same regional NCI designated Comprehensive Cancer Center affiliated with a University hospital. They did an MRI guided Transrectal Biopsy as they state they do NOT do Transperineal Biopsies. Results show all 12 cores as being BENIGN including samples taken from suspected 4 mm lesion or as they say ROI (region of interest). Recommended 6 months check-up and new PSA. I am dumb-founded. Contacted my PCP and he says "you still have cancer. they just didn't hit the cancerous area with the biopsy probe". How common is that? Anyone have any ideas or words of wisdom for me? Appreciate any and all comments!