I'm no medical expert, so what follows is just my 2 bit opinion. That said, here's my reaction to your post. As I understand it, the big picture is when you get an MRI that shows possible cancer, the next step is a biopsy to see if they find any cancer. If the biopsy misses the cancer and comes back "clean", or falsely only finds low grade cancer but misses higher grade cancer that is there, then you basicly wait a while and repeat various tests. So you really want your biopsy to be as effective as possible in hitting all the suspicious areas on the MRI so your follow-on decisions can be based on accurate data. My urologist offered to do the biopsy for me, but he told me that if I can afford it to go a cancer center of excellence (which was 300 miles away for me) where they have the latest technology (MRI fusion biopsy) to minimize the chance of a false "clean" report. Fortunately, my insurance allowed me to take his advice and they found cancer and I proceeded accordingly. Part of my decision was that the radiologist report of my MRI said it was about 50% chance of being cancer. I really wanted to have as much confidence in the biopsy, so that's why I traveled out of town. For me, it was worth it and I'm glad I both had the option and that I made the effort. Good luck with your decision and I hope you have the best possible results going forward.