Please let me know what he says to you! My injection won't be happening until the end of August...I realize that many people have reactions for so many different reasons, and I am in that 'place' now where I'd rather just not have the TKR. My pain/discomfort is totally 'doable' with cortisone shots, but they wear off at beginning of month 3 - but I've just read about a slow reaction cortisone that should last longer, so I might check that out. My pain that led me to a TKR was a torn meniscus that I chose not to repair, that led to osteoarthritis under my kneecap. We just got back from the Colorado River with family, and I got on and off of the boat with no problem, etc, and keep telling myself that I should not do a TKR until I am in so much pain that I can't stand it! Also, one other thing...I knew there was a small percentage of people that may have side effects such as yours with Iovera...so I will need to make the choice, when I'm ready for a TKR, if I want to take that chance..I am SO sorry that you have had to go through this. My surgeon only does 3 shots, and in the deep genicular nerves...was yours the genicular nerves or the peripheral nerves?