@cehunt57

I'm sorry to hear you have diabetes and kidney disease. I wish you the best of luck and healing. I will contact his endocrinologist to see what she thinks about the Prolia.

@isabelle7 and @cehunt57 Forteo and Prolia are NOT the same at all. Forteo is an anabolic that builds new (quality) bone through the parathyroid pathway.

From Drugs.com: Forteo is a man-made form of parathyroid hormone that exists naturally in the body. Teriparatide increases bone mineral density and bone strength, which may prevent fractures. Forteo is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. Forteo is for use when you have a high risk of bone fracture due to osteoporosis.

Prolia, like bisphosphonates, is an anti-resorptive that builds bone density by reducing bone turnover.

From UpTo Date online: "Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor kappa-B ligand (RANKL), an osteoclast differentiating factor. It inhibits osteoclast formation, decreases bone resorption, increases bone mineral density (BMD), and reduces the risk of fracture."

Prolia is different from all the other medications in the intensity of rebound when stopped.

Both need follow-up. Prolia needs follow up with Reclast (preferably) or alendronate.

Prolia and Forteo are entirely different classes of medications. It is better for many of us to do Forteo first. My docs avoid Prolia entirely because of the risks when stopping.