It works for me. I was a long time Gabapentin and Lyrica (Pregabalin) user and needed to change to another med to manage my peripheral neuropathy pain. The transition was rough. Duloxetine (Cymbalta) is a powerful medication. I had slight nausea, feelings of fatigue, and a sensation of being slightly disoriented. The initial dosage was 30 mg which was increased to 60 mg four weeks later for long-term maintenance.

Overall duloxetine has proven to be a better pain manager than the gabapentin and pregabalin mix that I was previously using, but for many people it has one very serious side effect - erectile dysfunction. Due to my age, past 80, and the age of my spouse, this is no longer an issue for us, but were we younger it would be quite significant.