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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: Oct 5 5:35pm | Replies (183)Comment receiving replies
65yo female; postmenopausal 11years. Dexa as of 03/2024
Region /Density(gm/cc)/T-score/Z-score
APspine L1-L4/ 0.76 / -2.6 / -0.8
FemoralNeck left / 0.588/ -2.4 / -0.8
Total Hip Left / 0.754/ -1.5 / 00.3
P1NP & CTx taken 11 wks after commencing Alendronate 70mg weekly. QuestDiagnostics labs taken same time; 6:00am; fasting and off collagen and biotin for 4days. P1NP =17 mcg/L. CTx =69 pg/mL which converted to mcg/L, I believe is .069. Unfortunately I don't have an original baseline prior to treatment.
Am taking additional supplements:
-3x week: K2 (MK7) 90mcg, D3 5000iu 3x week, CoQ10 50mg, methylated B12, biotin 5000mcg, iron bisglycinate 25mg. Starting after the tests - 50mg VitE Tocotrienols+75mgGG
-4x week: calcium hydroxyapatite 500mg & magnesium malate/glycinate 350mg
-daily - multi w/VitC,..; marine collagen 2.5g
Considering getting labs retested around 8mos. Any thoughts comments are appreciated.
Replies to "65yo female; postmenopausal 11years. Dexa as of 03/2024 Region /Density(gm/cc)/T-score/Z-score APspine L1-L4/ 0.76 / -2.6 /..."
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It is observed that in post menopausal women, almost no one's ctx is below 250 at baseline, with just a few exceptions. Once a bisphosphonate is started, a responder's ctx generally goes down a lot by week 12. In this case, fasamax. On average, ctx goes down by 50% by week 1 and 80% by week 12 of fosamax treatment. Ctx stays down (p1np too) as long as you stay on the med. Assuming your baseline ctx is 250 (rare, chances are you had a higher baseline ctx), you had a 72.4% reduction in ctx in 7 weeks of fosamax treatment! Please share your results if you are going to test again, if you could.
Curiously, what's the reason of supplementing methylated B12? Did you get tested for the need?
Thanks a lot?