@mmacaulay, you are wondering if in addition to darolutamide blocking the use of testosterone by the tumor cells, it may also be blocking uptake of testosterone in healthy cells and thereby causing general weakness. Am I understanding your question correctly?

I see others like @kam23 @sam60 @john6stodolka @digby2023 @lorenbk @ssaftler @hergiew and more have written about leg weakness related to Lupron in these discussions:

- Lupron Depot: Weakness and instability side effects
https://connect.mayoclinic.org/discussion/lupron-depot/
- Lupron: Anyone have muscle weakness and severe leg pain?
https://connect.mayoclinic.org/discussion/lupron-muscle-weakness-and-severe-leg-pain/
For some the weakness resolved over time. @mmacaulay, How long has it been since you stopped treatment with chemo and Lupron? How long have you been on darolutamide?