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PSA rise

Prostate Cancer | Last Active: Jul 14 9:37am | Replies (9)

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@stevegrant333

PSA

Note:
10/20/2023 PSA was 20
06/13/2024 PSA was 27
07/09/2024 PSA was/is 33

Digital exam: Prostate size not enlarged

Does anyone know what else can generate the above PSA numbers?

The next decision is the biopsy. If all else is normal with the prostate, I question the decision/option of the biopsy. If the decision is to go forward, the question moves to which biopsy format. Any thoughts/guidance would be appreciated.

Thank you in advance

* * *Final Report* * *

DATE OF EXAM: Jun 13 2024 12:00AM

OUT 0001 - MR OUTSIDE CD DICOM IMPORT -NBNR / ACCESSION # 154275465

PROCEDURE REASON: The previous report is inadequate.

* * * * Physician Interpretation * * * *

EXAMINATION: OUTSIDE IMAGING INTERPRETATION

Indication for the Request / Reason for Overread: Previous report is
inadequate.

Service Requesting Consult: Urology

Any specific Issue(s) to be discussed: PROSTATE BIOPSY TARGETING NEEDED
FOR TRANSPERINEAL BIOPSY

Images Reviewed: MR without and with contrast of the Pelvis performed on
6/13/2024 12:00 AM

Overread Date: 7/1/2024 9:41 AM

CLINICAL HISTORY: 76 years old being evaluated for prostate cancer. No prior biopsy.
Previous biopsy: None.
PSA: 20 ng/mL (10/20/2023) ;
Prior therapy: None.

COMPARISON: None

RESULT:

Prostate:

Dimensions: 4.6 x 3.8 x 3.4 cm corresponding to a volume of approximately
31 cc.

Post-biopsy hemorrhage: Absent

Peripheral zone: Diffuse mild T2/ADC map hypointensity (PI-RADS 2).

Transition zone: There is transition zone hypertrophy, without focal
abnormalities suspicious for clinically significant disease (PI-RADS 1).

Neurovascular bundle: Unremarkable.

Seminal vesicles: Unremarkable.

Adjacent Organ Involvement: Not applicable.

Lymph nodes: No enlarged pelvic lymph nodes.

Bladder: Unremarkable.

Pelvic bones: No suspicious pelvic osseous lesions.

Other Findings: There are bilateral moderate-sized fat-containing
inguinal hernias.

IMPRESSION:

1. No suspicious prostate lesion. Maximum PI-RADS category: 2.

2. Prostate volume is approximately 31 cc.

==========================================
Number of targets created for MR/US fusion biopsy:
Full gland segmentation performed in Koelis to permit nontargeted
transperineal fusion biopsy.
Peripheral zone: 0
Transition zone: 0

If present, targets were numbered in order of level of suspicion for
clinically significant prostate cancer (Gleason score 3 + 4 or higher).

PI-RADS v2.1 Assessment Categories:
PI-RADS 1: Clinically significant cancer is highly unlikely
PI-RADS 2: Clinically significant cancer is unlikely
PI-RADS 3: Clinically significant cancer is equivocal
PI-RADS 4: Clinically significant cancer is likely
PI-RADS 5: Clinically significant cancer is highly likely

(V.05.2019)

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Replies to "PSA Note: 10/20/2023 PSA was 20 06/13/2024 PSA was 27 07/09/2024 PSA was/is 33 Digital exam:..."

A biopsy really is indicated just to be certain. Go with the TRANSPERINEAL by an experienced urologist. Not only is it painless (when done properly with nerve blocks or sedation) but it is also more accurate since it can access more of the gland and get samples that might be missed by transrectal approach and give you a false negative result. Just my opinion based on my experience. Best of luck going forward!

In my mind, this prostate has cancer until proven otherwise. Biopsies, even 12-20 random pokes, will be more sensitive than MRI. An MRI is basically shadows created by a computer based on the effect of changing the spin of hydrogen molecules in tissues ... pretty indirect, and level of resolution is less than the microscopic vision of the actual cells themselves which the biopsy obtains.