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HRT Safety

Osteoporosis & Bone Health | Last Active: Jul 21 6:54am | Replies (80)

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@lynn59

Hi Debbie1956. I’m from Canada too. We have a new bio-similar, ONERO, available in Canada that is half the price of Forteo. I started it 3 months ago. At first I had some serious side effects (extreme fatigue, heart palpitations) but I stuck with it and the side effects disappeared after a month thankfully.

I’m 65 years old with T-scores similar to yours. DEXA shows -3.3 in spine and -2.8 in hips. My REMS scan showed slightly better results and my bone quality was still in the green (bordering orange). I haven’t fractured yet. I downhill ski fairly aggressively, backcountry ski, and cross country ski in the BC during the winter months, so I felt I had to build bone to continue doing these sports. I was reticent to try Evenity as it is relatively new compared to the use of teraparatide, plus I have a family history of cardiovascular problems, so until speculations of it causing heart issues are proven wrong, I’m sticking with ONERO for two years, likely followed by an oral bisphosphomate or maybe Reclast (although that makes me a little nervous). I’d love to try HRT, but cardiologist says since there are other options to mitigate bone loss open to me right now, it’s probably better to use those (I’m 17 years post menopause). I hope after 3 years of drug therapy (2 yrs ONERO, 1 yr Actonel), I can take a drug holiday for at least 3-5 years. Then I might try Evenity? Or another round of teraparatide?

Good luck with your journey and I’m sure I’ll be reading your input to this site again. We have some wonderful contributors.

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Replies to "Hi Debbie1956. I’m from Canada too. We have a new bio-similar, ONERO, available in Canada that..."

Hi @lynn59 , Thanks so much for the information on ONERO and your experience on it. I hadn't heard of it. Yes our DEXA and REM results are very similar and I am about 14 years post menopause. I too love cross country skiing and thought it was too risky for me now, so am encouraged by your perseverance. I feel much better with the Estradot patch rather than the oral as it bypasses the liver, though it is not entirely risk free as no medications are. There are zero side effects except better sleep which is wonderful. Regarding my A1c response to Berberine, I have little doubt the Berberine reduced it from 5.6 to 5.2, however, I have kept it below 6 with a low carb, mediterranean type diet, and an Alpha Lipoic Acid supplement, also known to lower glucose levels, for several years after prediabetic diagnosis. I take other supplements which likely help as well, but there was a dramatic drop again after Berberine. I'll be very interested to hear your results after the full course of ONERO. Thanks again for sharing this. Yes we do have some wonderful contributors here.