All meds can become ineffective over long term use. Our bodies are built to build immunity to Harmful/Toxic things. Synthetic Drugs are considered foreign toxic chemicals to our body.
Ask your Rheumatologist about different options. TiZanidine may be helpful. Consume lots of Magnesium and Turmeric. Also highly recommend Red Light/Infrared Therapy and Ice baths or CryoTherapy. I can’t do ice baths, but Cryotherapy isn’t too bad and it’s SUPER good for you and MIGHT help reset your body.
Good Luck!