Actemra (tocilizumab) allowed me to taper from 10 mg to 3 mg. PMR was well controlled but my cortisol level was low. The management of my Prednisone dose was turned over to an endocrinologist. I needed to stay on 3 mg of prednisone for six months before my cortisol level improved. The endocrinologist gave me the green light to discontinue prednisone.

My liver enzymes rose slightly after I started Actemra. I was referred to a liver specialist who said it was because of nonalcoholic fatty liver disease (NAFLD) likely caused by long term prednisone use.
https://www.healthline.com/health/prednisone-and-fatty-liver-disease#:~:text=Can%20prednisone%20increase%20your%20risk,even%20cause%20drug%2Dinduced%20diabetes.
The liver specialist said the NAFLD wasn't that severe so Actema didn't need to be stopped.