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Replies to "I just took my first dose of 20 mg duloxetine and I’m not enjoying the way..."
Chronic Pain | Last Active: Nov 20, 2025 | Replies (29)
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I just took my first dose of 20 mg duloxetine and I’m not enjoying the way I feel at all. How long before this one dose wears off? Doc prescribed it to replace gabapentin for neuropathy but I’m sure I won’t make it through the time it takes to start working. Should I decide to move forward (VERY much on the fence), does it contribute to constipation at all? Definitely won’t make it if it does.
Replies to "I just took my first dose of 20 mg duloxetine and I’m not enjoying the way..."
@carolinlv Just taken my first 30mg of Duloxetine last night never again.
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I use 90 mg of ER duloxetine at bedtime - morning use didn't work at all for me either, but I was so miserable I stuck with my pain doc and figured out what works - we started with 30, then 60, and recently increased to 90 - all at bedtime. The ER (extended release) is much easier to tolerate as it is released slowly into the body.