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What exactly is NED (no evidence of disease)?

Pancreatic Cancer | Last Active: Jul 9 6:43am | Replies (20)
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@markymarkfl

dostarlimab aka TSR-042

I'd never heard of it before your post, but it looks promising in tumors with certain properties.
https://newatlas.com/medical/colorectal-cancer-dostarlimab-gxly
I found over 50 hits for it on the government trials site.

This one explicitly mentioned pancreatic cancer as a condition being treated: https://clinicaltrials.gov/study/NCT04673448

Pancreatic cancer as long as it's not assoc w/ a BRCA mutation:
https://clinicaltrials.gov/study/NCT04983745
I might have missed a few.

In some cases, "pancreatic cancer" might not be listed in the search criteria, but the trial could still be open to patients with "solid tumors" so don't ignore those!

Also, some studies only list the treatment drug by its investigational name (TSR-042) rather than a commercialized name, so try to always include both in a search.

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Replies to "dostarlimab aka TSR-042 I'd never heard of it before your post, but it looks promising in..."
marienewland | @mnewland99 | Jul 9 6:43am

Thanks markymarkfl that info is very helpful! I like the looks of the last link in Tennessee and it does sound promising. I’ve never been sure if I’m germline or somatic. I had be Ambry blood test before my surgery and it came back negative. After my surgery, tissue samples were evaluated and it showed I had an ATM mutation, KRAS12D mutation, and TP53 mutation. My father had pancreatic cancer and his mother had breast cancer in her 40’s, so it must be germline; but very confusing with the evidence. Apparently I have an abdominal hernia that my dr doesn’t want to do anything about so things are complicated now.

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