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Time to Castrate Resistance: Anyone remained castrate sensitive 5+ yrs
Prostate Cancer | Last Active: Oct 29 10:14am | Replies (25)Comment receiving replies
I know the statistics. What I am asking is for peoples personal experience with regard to time to castrate resistance. For example, there are other threads where people have asked if anyone has lived longer than 10 years with metastatic prostate cancer. And thank God, several people responded and others reading were encouraged. I'm looking for others to chime in with there personal journeys with regard to the length of time they remained castrate sensitive. For example, I am at the 2 year mark. But I was treated based on triplet therapy based on the ARSENS trial. To date, time castrate resistance has not been reached with that study. Because the men in that study that received 6 cycles of chemo, ADT, and Darolutamide are still alive and many still castrate sensitive. I'm asking if there are other out there that are still castrate resistant after several years 5, 10 etc.
Replies to "I know the statistics. What I am asking is for peoples personal experience with regard to..."
Hi @wooldridgec. I am so happy to hear that you are currently receiving triplet therapy. You should definitely feel encouraged and rest assured that you are receiving cutting edge treatment. As you mentioned, the results from the ARASENS study definitely show a huge improvement in the time to castrate resistance which is encouraging. My father, like you, is currently receiving triplet therapy and is over one year now since the start of his treatment, and remains hormone sensitive.
One small correction I did want to point out (sorry, I am a bit of a statistics nerd), is that it is unfortunately not the case that castrate resistance was never reached amongst the triplet therapy group in the ARASENS trial (if I am understanding you correctly). What was not reached by the time the data was analyzed (approximately four or five years after data collection started?) was the median time to castrate resistance. Median in statistics is the point at which a half-way mark is reached, kind of like the median in the middle of the road. It is the point in time where exactly half of the group reaches a given endpoint (in this case, castrate resistance), and the other half does not. By saying that the median time to castrate resistance has not been reached, they are basically saying that from the beginning of the study until the time of analysis, the point in time where half of the triplet group have become castrate resistant has not yet been reached. In other words, after four years, more than half of the individuals in the triplet therapy group have not reached castrate resistance (by that time, only 225 out of 651 - or 35% - of the triplet therapy participants had become castrate resistant).
I have attached the graph from the ARASENS trial for your reference, where you can see over time on average what the time to castrate resistance might look like over a four/five year period (for those with triplet therapy and those without).
Take care,
Phil
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I have APC and did 4 rounds of chemo followed by 3 month cycled Lupron injections. In 2019 was switched to ORGOVYX . Have had PSA 0.02 levels since. Side effects have increased but manageable with exercise. So have been castrate sensitive for more than 5 years. I am 74 yo. My oncologist does not recommend taking a break from treatment.