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What exactly is NED (no evidence of disease)?

Pancreatic Cancer | Last Active: Jul 9 6:43am | Replies (20)

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@mnewland99

Thank you, Maryanne. I wish you success! The little understanding I have of this disease, is that you have to attack it from several fronts. I believe immunotherapy is the key to success. My hunch is that masses in my abdominal area are no longer stable, the strong chemo seemed to attack those liver lesions well. My oncologist told me a few months ago that the abdominal masses would be the ones to worry about so that’s why I’m asking my drs to go into the CLD-18.2 trial that tries to attack gastric cancer but how long it can be effective is still in the works. A KRAS-12D trial would seem to be the next step (I don’t know of any trials for ATM mutations) after CLD18.2 so please let me know how it goes! God bless you in your fight.

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Replies to "Thank you, Maryanne. I wish you success! The little understanding I have of this disease, is..."

And to you! I feel great so hoping this is the best time to try an alternative strategy. My first real assessment will be in 8 weeks. I’ll definitely write what is found.

Be aware that ATM mutations are being treated in trials by drugs called ATR-inhibitors (not ATM inhibitors). There have been a few.

berzosertib (formerly M6620, VX-970)
ART0380
Elimusertib (BAY-1895344)
Comonsertib
https://aacrjournals.org/cancerdiscovery/article/11/1/80/3075
https://news.vumc.org/2021/09/23/clinical-trial-tests-atr-inhibitor-in-difficult-to-treat-cancers/
Dr. Yap (in this article: https://www.mdanderson.org/newsroom/results-fgfr-inhibitors-parp-atr-inhibitor-combinations.h00-159617856.html ) is a clinical trial-generating machine, with focus on the DDR deficient mutations like ATM.