It's so challenging to be patient! I have been trying to find the right medication for over a year and have had to pull back from most of my commitments since I am not in a good place mentally/emotionally. I was on Effexor for years, and it worked very well until it didn't. I was then transitioned to Fetzima which was a disaster. My next try was Zoloft and I felt more like myself than I have in a long time, but I began putting on weight. Then we moved to Trintellex which doesn't seem to help at all. I'm hoping to move back to Zoloft and try to deal with the weight issue.