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Treatment options: radiation without ADT?

Prostate Cancer | Last Active: Jul 28 9:17am | Replies (39)

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@heavyphil

I had a Gleason 7 unfavorable (4+3) confirmed by surgical pathology. I know of the recent studies concerning ADT with salvage radiation, but never heard that ADT is contraindicated in most cases of Gleason Intermediate. Can you post a link? I am meeting radiation oncologist at Sloan next week and I would like something to dissuade (ha!) him from putting me on hormones. Much appreciated!

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Replies to "I had a Gleason 7 unfavorable (4+3) confirmed by surgical pathology. I know of the recent..."

Hi Phil! Sounds like you had surgical removal of your prostate and the pathology confirmed Gleason 7 (4+3). I also assume that you have had a PSMA Pet Scan confirming the disease is confined to the prostate. Not sure the accepted Standard of Care protocol is exactly the same with respect to ADT administration for prostate removal vs SBRT Proton Radiation (which I had). But either way, I encourage you to watch the recent PCRI video narrated by Dr. Mark Scholz (medical oncologist) which addresses the newly published findings from a legitimate trial study regarding new thinking on the net benefits of ADT supplementation in the context of patients receiving radiation of the prostate. Dr. Scholz feels that the findings will ultimately lead to the standard of care for localized Gleason 4+3 prostate cancer to not recommend ADT as a part of treatment due to potential metabolic health risks of ADT not justifying fractional improvements in cancer recurrence or survival statistics. Because standards of care are slow to change and doctors rely on these to avoid future liability, I do not anticipate the new findings are going to be universally endorsed by individual urologists or radiologists. But the findings certainly do arm you with another legitimate discussion point relative to the ADT - No ADT decision. It will still be your decision but it might at least open up some true grit discussion that your doctors otherwise would be more casual or non-communicative about. If I had had the benefit of this new research in 2022, I am confident I would have foregone the 6 months of ADT. Just be assertive and don't rush a decision on ADT. It's nasty stuff on metabolic health no matter how good of shape you are in. I hope this helps.

You don't say how old you are. There is a study about ADT not making much difference in Biochemical or overall survival if you are over 70. I was one core at 4-3 and two at 3-4 and was over 73.