I have been on Trintellix for about a year. Not sure if I’m on 10 or 20 mg.
After about 4 weeks of tapering up in dose, I started to feel like my old self again. Only medication that has worked successfully and consistently. Only problem is the cost since my insurance has a $160 copay. They do have a program through manufacture that takes off $100 per month.
One suggestion would be to get a medical test that shows based on your genetic makeup what anti-depressants or other medications like pain meds are best for you. Eliminate me a lot of trial & error. Good luck!