Maudsley® Deprescribing Guidelines
reductions made every 2-4 weeks.
Step
RO (%)
Dose (mg)
88.4
300
Use tablets/capsules
150
Use tablets/capsules
86.7
112.5
Use tablets/capsules
CHAPTER 2
2
3
4
85.7
83.6
75
Use tablets/capsules
Switch to venlafaxine 7,5mg/mL solution*
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
81.5
55
3.67mL (twice daily)
25
26
27
28
29
30
79.8
45
3.00mL (twice daily)
77.6
37.5
2.50mL (twice daily)**
75.7
30.4
2.03mL (twice daily)
73.7
26
1.73mL (twice daily)
71.7
22.6
1.51mL (twice daily)
69.7
19.8
1.32mL (twice daily)
67.7
17.5
1.17mL (twice daily)
65.7
15.6
1.04mL (twice daily)
63.7
14
0.93mL (twice daily)
61.7
12.6
0.84mL (twice daily)
59.7
11.4
0.76mL (twice daily)
57.7
10.4
55.7
0.69mL (twice daily)
9.4
53.8
0.63mL (twice daily)
8.6
51.8
7.8
0.57mL (twice daily)
49.8
7.2
0.52mL (twice daily)
31
32
33
34
35
36
37
38
39
40
41
42
43
44
47.8
6.6
0.48mL (twice daily)
45.8
6
0.44mL (twice daily)
43.8
5,5
0.40mL (twice daily)
0.37mL (twice daily)
See further steps in the right-hand column
45
46
47
RO = receptor occupancy
41.7
5
Volume
39.8
4.6
37.8
4.2
0.33 mL (twice daily)
35.7
0.31 mL (twice daly)
3.8
33.9
0.28mL (twice daily)
3.5
0.25mL (twice daily)
32.0
3.2
0.23mL (twice daily)
Switch to venlafaxine 0.75mg/mL dilution*
0.21 mL (twice daily)
30.0
2.9
27.9
2.6
1.93 mL (twice daily)
25.6
2.3
1.73 mL (twice daily)
23.5
2.05
1.53mL (twice daily)
21.3
1.8
1.37 mL (twice daily)
19.5
1.6
1.2mL (twice daily)
17.5
1.4
1.07 mL (twice daily)
16.0
1.25
0.93 mL (twice dally)
14.4
1.1
0.83 mL (twice daily)
12.7
0.95
0.73 mL (twice daily)
10.9
0.8
0.63 mL (twice daily)
9.1
0.53mL (twice daily)
0.65
7.1
0.43mL (twice daily)
0.5
5.1
0.33mL (twice daily)
0.35
0.23mL (twice daily)
Switch to venlafaxine 0.075mg/mL dilution*
3.0
1.5
0.2
0.1
0
0
1.33mL (twice daily)
0.67mL (twice daily)
0
out beads or making a suspension are outlined above.
our are on on al, the of label options for making up smal doses including masans

I’m so grateful to have found this message board. I’ve been reading about others’ experiences and recommendations over the last few weeks. I’ve been fortunate to have an easy time titrating to 37.5mg, and my regular dose was just 75mg ER for about 2.5 years.

I’m now scheduled to take the 37.5 every other day for two weeks, potentially longer if needed. Saturday (two days ago) was my first skip day and I had some dizziness, felt disconnected, trouble focusing, tingling in my face, and pretty severe pain in my muscles and joints. The worst was my hips and legs.

Ibuprofen, naproxen, and Benedryl have been helpful.

Sunday, I took 37.5 but my symptoms were worse than Saturday. Tosay was a skip day, and I feel dizzy, nauseous and achy. And very disconnected. It’s challenging to hold a conversation. And I ended up taking a half day off work due to the symptoms.

I have a new symptom today and I cannot find anything online and it’s freaking me out some. I’m having vision issues where my floor in my house looks like it is swirling. My floor has a light marbling pattern and it is swirling around. Has anyone else experienced this? I got really fearful and started worrying that I was losing touch with reality/ having a psychotic break. I’m laying down now and trying to focus on my breathing but still feeling very panicky.