I just began a protocol with bioidentical hormones after completing 2 years on Tymlos. I had an 11% gain with Tymlos injections and don’t want to be on another osteo med if possible. My cardiologist, who runs my bloods suggested hormone replacement to hold my gains. Plus, I am completely hormone deficient so this route seems sensible. I am on a 0.025 mg estradiol patch, 125 mg progesterone capsule and 0.5 mg testosterone cream. It’s only been a little over a week so we’ll see how it goes. Praying that I’ll sleep better, less hair loss, feel more energetic, not so cranky, less wrinkles but of utmost importance are my bones. I am severely osteoporotic but have never fractured, thank God. I’m very active, (hiking, pickleball, cardio, weights) so stronger bones is my first and foremost concern. Hormone replacement isn’t well received by many doctors because of flawed research in the early 2000’s. My cardiologist is very well educated in HRT and feels confident that this is the route for me. I am 72 and had a complete hysterectomy in my late 30’s, went on synthetic hormones for a short time, then stopped. Therein my severe bone loss. Praying the future will bring stronger bones and a happier me!