@birdman518: Thank you for starting this thread!

I normally post/comment in the PCa group, but recently added this group to my "watchlist". I'm a retired chemical engineer, who spent most of my career in research, and was diagnosed with PCa in October 2023. I'm currently on Active Surveillance (AS), you can see my profile for details.

I began my PCa journey by implementing a whole plant food diet (virtually the opposite of Keto); but more importantly (at least in my mind) I upped my aerobic running regiment (by ~3x) to three 5K runs per week.

After three months on a whole plant food diet, my PSA dropped 25% from its prebiopsy level, I lost 25 lbs and experienced a lot of beneficial health side effects. However, I began to notice some negative effects regarding slowed healing of superficial skin wounds. Because of that, and the fact that I didn't want to lose any more weight, I introduced (grass fed beef, chicken and/or wild caught salmon) into my diet...one serving per day. Three months after that change, at my 6 month PSA check, my weight had remained the same and my PSA was still the same...25% lower than prebiopsy.

I note @gisellef's comment regarding Dr. Peter Attia's book "Outlive". My urologist recommended his book 3 months ago. Dr. Attia's findings/recommendations, regarding VO2 Max, confirmed my "aggressive" AS plan, and my VO2 Max has increased from 40 to 49, since my PCa diagnosis. According to Dr. Attia, a VO2 Max of 46 is considered at the "elite" level (top 2.3%) for a man in the 60-69 age group. See attached chart...somewhat busy...I like numbers 🙂

So a couple weeks ago I came upon Dr. Thomas Seyfried...he's a biochemist on steroids! I listened to a lot of what he had to say, via YouTube videos, and decided to purchase his original book "Cancer as a Metabolic Disease". I'll get my copy this week and I'm looking forward to reading his original work...mathematics and chemistry have always been my favorite subjects.

I understand his premise is that without glucose and glutamine cancer cells die. The bad news is that normal, health cells also need these compounds to function and thrive. I suppose his argument is that cancer cells die without glucose and glutamine; while our normal cells just go into a sort of "paralytic" (hibernation like??) state...therefore his "Press Pulse" treatment methodology is meant to progressively kill and weaken the cancer cells and then bring back the "fuel" to "reawaken" the normal cells to clean up the "dead bodies"...of course that also nurses any leftover of cancer cells back to health...so it's on to another round...etc. I'm sure there is much more to it...I'm looking forward to reading his book to better understand what he found and is recommending.

Not sure if any Mayo researchers are currently studying DON (6-diazo-5-oxo-L-norleucine)... or DON prodrugs, but Hopkins was doing so about 5 years ago.

It seems to me that one has a "minor" practical issue as to where you would even get the appropriate dosage and scheduling of DON (or these "prodrugs") even if you wanted to try that approach. I'd want to know how one attacks the glutamine issue (without being able to get DON) before embracing a keto diet to reduce glucose....just some musings..........