I went through Humira, Entyvio (every mo) and Stelara (every month) and failed on each. Biologics did not work for me.

I finally got good results with Rinvoq. That is the latest in the line of Xeljanz, Zeposia and then Rinvoq. Rinvoq does particularly well with people (like me) who already failed on other meds. I had mucosal healing and a major reduction in inflammation. You might want to ask about Rinvoq.

(Unfortunately, although it helped with UC, it did not prevent conversion of high dysplasia into colon cancer, so I then chose a full procto-colectomy with end ileostomy.)