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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: Oct 5 5:35pm | Replies (183)Comment receiving replies
Just received my bone marker test result. They are fasting for 12 hours and blood drawn before nine am, as instructed by ordering physician:
CTX 231
P1NP 41
Also, (not listing very long results, but what seems most applicable here):
PTH Intact 23
Serum calcium 10.0 (was 10.1 12/23 before supplementing).
I am not yet on meds, but make sure to get 1200 mg calcium supplements /food daily and d3. No other supplements yet (have on list for doc magnesium and K).
My dexa was -3.6 spine and osteopenia everywhere else.
Replies to "Just received my bone marker test result. They are fasting for 12 hours and blood drawn..."
Hi @babbsjoy am glad that you had your baseline bone markers done. Your ctx looks great, while p1np could be better (higher). It's great that your endo is ruling out secondary causes. keep in mind also that certain meds such as corticosteroids, PPIs, SSRIs and AI etc. as well as certain conditions like kidney diseases, IBS or thyroid problems to name a few could have negative impacts on bone health. Osteoporosis has a heterogeneous etiology, but many postmenopausal women have it as a result of estrogen difficiency.
I had almost the same dexa results as you do at the time of diagnosis, although I'm a few years younger than you are. What's your frax number, if you don't mind me asking? With typical postmenopausal osteoporosis due to estrogen difficiency where L spine (trabacular in nature hence more bfu gets affected) were more deteriorated than hip or femur neck, Forteo or Tymlos are wonderful choices. Monitoring bone markers during therapy is a tool to check if the drug is working. What's more, btms could be used to guide therapy duration as well as for future plans should you elect a second course of anabolic therapy.
Please keep us posted.
Best wishes!
Could you please mention in what units are CNX and P1NP? It would be interesting to know also how your doctor commented your results?
babbsjoy, You're not on any osteo meds? Have you ever taken any? I ask, because your BTMs are actually pretty darn good. Dr. McCormick, author of Great Bones, says the ideal P1NP range is 20-60, and CTx should be 350 (375 at a stretch) or less. The ratio of P1NP to CTx, per Dr. Mc should ideally be somewhere around 1 to 10 to *maintain* bone if you're not on meds. Yours is about 1.75 to 10. That ratio, implies that you should be growing bone. Bear in mind--your scores are a snapshot, and could vary by quite a bit day-to-day, but I would kill for scores like that when I eventually try to go med free.
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@babbsjoy, I'm sorry babbs, what was your history ? Have you just begun to decide on an osteodrug? What was your reason for this test?